获取药物adme详情
<p>[TOC]</p>
<h5>简要描述</h5>
<ul>
<li>获取药物adme详情</li>
</ul>
<h5>请求URL</h5>
<ul>
<li><code>http://119.136.27.201:3200/drug/discovery/library/detail/adme</code>
<h5>请求方式</h5></li>
<li>GET</li>
</ul>
<h5>参数</h5>
<table>
<thead>
<tr>
<th style="text-align: left;">参数名</th>
<th style="text-align: left;">必选</th>
<th style="text-align: left;">类型</th>
<th>说明</th>
</tr>
</thead>
<tbody>
<tr>
<td style="text-align: left;">compound</td>
<td style="text-align: left;">是</td>
<td style="text-align: left;">string</td>
<td>药物编号</td>
</tr>
</tbody>
</table>
<h5>返回示例</h5>
<pre><code>{
'data': {
'Basic physicochemical property': [
['MW', 'MW', '459.55', ['Pass'],
['&lt;500']
],
['KS', 'pH=7.4 μM/mL 2% DMSO;pH=7.4 μg/mL 2% DMSO', '144.67/66.48', ['Pass', 'Pass'],
['&lt;250mL', '&lt;250mL']
]
],
'Absorption': [
['MDCK-BCRP (1 μM)', 'Papp (A-B);Efflux Ratio;Papp (B-A)', '8.46/2.63/21.9', ['Pass', 'Pass', None],
['&gt;2*10-6 cm/s', '&gt;2', None]
],
['MDCK-MDR1(1 μM,10μM PSC833)', 'Papp (B-A);Papp (A-B);Efflux Ratio', '17.41/15.51/1.12', [None, None, 'Fail'],
[None, None, '&gt;0.5']
]
],
'Distribution': [
['mPPB% bond (5 μM)', 'dog;mouse;human;rat', '86.11/61.4/90.16/87.36', ['Pass', 'Pass', 'Pass', 'Pass'],
['&lt;99%', '&lt;99%', '&lt;99%', '&lt;99%']
],
['mBPB% bond (1 μM )', '', '90.76', ['Pass'],
['&lt;99%']
]
],
'Metabolism': [
['CYP induction ( CYP3A4 ) (1 μM,American Indian)', 'Hepatocytes cell viability at 1 µM;Fold of induction;Induction % positive control', '59.6±2.50/0.000899/-4.01', ['Fail', 'Pass', 'Pass'],
['&gt;90%', '&lt;2', '&lt;20%']
],
['CYP induction ( CYP3A4 ) (0.03 μM,Caucasian)', 'Hepatocytes cell viability at 1 µM;Induction % positive control;Fold of induction', '114±8.67/-2.23/0.374', ['Pass', 'Pass', 'Pass'],
['&gt;90%', '&lt;20%', '&lt;2']
]
],
'Toxicity': [
['mini-AMES(ratio of mean revertants at the peak of the dose response)', 'TA100: +S9;TA100: -S9;TA98: -S9;TA98: +S9', '1.27/1.25/1.17/1.16', ['Pass', 'Pass', 'Pass', 'Pass'],
['&lt; 2', '&lt; 2', '&lt; 2', '&lt; 2']
],
['GSH trapping in HLM(10 μM)', 'parent% at 60min;Biotransformation;GSH adduct% at 60min', '0.839/Oxidation+GlutathioneConjugation/0.0011', ['Fail', None, 'Pass'],
[None, None, '&lt;0.5%']
]
],
'PK (Pharmacokinetics)': [
['mouse PK: po (10 mpk) (10 mpk,TFA salt)', 'AUC (h*ng/mL);Cmax(ng/mL);T1/2(h);F%', '2265/272/2.9/53.9', [None, None, 'Fail', 'Pass'],
[None, None, '&gt;4', '&gt;50%']
],
['mouse Brain Kp,uu: iv (1 mpk)(1, 4, 8 h) (Plasma)', 'T1/2 (h);Vss (L/kg);Cl (mL/min/kg)', '2.04/4.98/32.9', ['Fail', 'Fail', 'Fail'],
['&gt;4', '&gt;5', '&lt;27']
]
]
},
'code': 200,
'message': 'success'
}</code></pre>
<h5>返回参数说明</h5>
<table>
<thead>
<tr>
<th style="text-align: left;">参数名</th>
<th style="text-align: left;">类型</th>
<th>说明</th>
</tr>
</thead>
<tbody>
<tr>
<td style="text-align: left;">Basic physicochemical property</td>
<td style="text-align: left;">list</td>
<td>表头为Basic physicochemical property的表格数据， 每个对应一行中1-4格显示内容和隐藏的解释</td>
</tr>
</tbody>
</table>
<h5>备注</h5>