获取 Splicing Target Discovery-Compound 单药物详情页 （Regi
<p>[TOC]</p>
<h5>简要描述</h5>
<ul>
<li>获取 Splicing Target Discovery-Compound 单药物详情页 （Region部分）
<h5>请求URL</h5></li>
<li><code>http://119.136.27.201:3200/discovery/compound/detail/region</code>
<h5>请求方式</h5></li>
<li>GET</li>
</ul>
<h5>参数</h5>
<table>
<thead>
<tr>
<th style="text-align: left;">参数名</th>
<th style="text-align: left;">必选</th>
<th style="text-align: left;">类型</th>
<th>说明</th>
</tr>
</thead>
<tbody>
<tr>
<td style="text-align: left;">offset</td>
<td style="text-align: left;">是</td>
<td style="text-align: left;">int</td>
<td>分页偏移量</td>
</tr>
<tr>
<td style="text-align: left;">limit</td>
<td style="text-align: left;">是</td>
<td style="text-align: left;">int</td>
<td>分页大小</td>
</tr>
<tr>
<td style="text-align: left;">compound_id</td>
<td style="text-align: left;">是</td>
<td style="text-align: left;">string</td>
<td>药物id，使用discovery/rna_seq 接口中compound_id字段</td>
</tr>
<tr>
<td style="text-align: left;">gene</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">string</td>
<td>gene筛选，多选以“,”分隔</td>
</tr>
<tr>
<td style="text-align: left;">order</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">string</td>
<td>倒序字段，可选："Delta psi (Down Intron/ Reference Intron)", "Delta psi (Up Intron/ Alternative Intron)", "CHX Delta psi (Down Intron/ Reference Intron)","CHX Delta psi (Up Intron/ Alternative Intron)", "diffExon log2FC", "diffExon padj","CHX diffExon log2FC", "CHX diffExon padj", "diffGene log2FC", "diffGene padj"</td>
</tr>
<tr>
<td style="text-align: left;">desc</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">int</td>
<td>排序是否倒序 1：是， 0：否 默认1</td>
</tr>
<tr>
<td style="text-align: left;">Type</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">string</td>
<td>Type筛选</td>
</tr>
<tr>
<td style="text-align: left;">diffExon log2FC</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">number</td>
<td>diffExon log2FC筛选，填入”diffExon log2FC<“ 框内的数值</td>
</tr>
<tr>
<td style="text-align: left;">diffExon padj</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">number</td>
<td>diffExon padj筛选，填入”diffExon padj <“ 框内的数值</td>
</tr>
<tr>
<td style="text-align: left;">diffGene log2FC</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">number</td>
<td>diffGene log2FC筛选，填入”diffGene log2FC <“ 框内的数值</td>
</tr>
<tr>
<td style="text-align: left;">diffGene padj</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">number</td>
<td>diffGene padj筛选，填入”diffGene padj <“ 框内的数值</td>
</tr>
</tbody>
</table>
<h5>返回示例</h5>
<pre><code>{
'data': {
'table': {
'total': 220,
'limit': 4,
'offset': 0,
'regions': [{
'gene': 'KDSR',
'compound': 'RC00000028_3µM_24hr-20221223',
'Type': 'Cassette Exon',
'Region': 'chr18:63339688-63341080',
'Sequence (Donor)': 'GGAGGTAAAA',
'PTC Position': '63341061',
'Strand': '-',
'Delta psi (Down Intron/ Reference Intron)': 1.0,
'Delta psi (Up Intron/ Alternative Intron)': 1.0,
'CHX Delta psi (Down Intron/ Reference Intron)': None,
'CHX Delta psi (Up Intron/ Alternative Intron)': None,
'diffExon log2FC': 3.908,
'diffExon padj': '1.016e-08',
'CHX diffExon log2FC': None,
'CHX diffExon padj': None,
'diffGene log2FC': -3.807,
'diffGene padj': 0.0,
'CHX diffGene log2FC': None,
'CHX diffGene padj': None,
'htt_activity': 3.0,
'compound_url': 'https://revirtx.benchling.com/revirtx/f/lib_Nz4dgQWg-registry/mol_8ZMV7Oqf-rc00000028/edit'
}, {
'gene': 'SNX4',
'compound': 'RC00000028_3µM_24hr-20221223',
'Type': 'Cassette Exon',
'Region': 'chr3:125470566-125472483',
'Sequence (Donor)': 'AGAGGTGAGG',
'PTC Position': '125472442',
'Strand': '-',
'Delta psi (Down Intron/ Reference Intron)': 0.928,
'Delta psi (Up Intron/ Alternative Intron)': 1.0,
'CHX Delta psi (Down Intron/ Reference Intron)': None,
'CHX Delta psi (Up Intron/ Alternative Intron)': None,
'diffExon log2FC': 2.342,
'diffExon padj': '3.996e-13',
'CHX diffExon log2FC': None,
'CHX diffExon padj': None,
'diffGene log2FC': -3.265,
'diffGene padj': 0.0,
'CHX diffGene log2FC': None,
'CHX diffGene padj': None,
'htt_activity': 3.0,
'compound_url': 'https://revirtx.benchling.com/revirtx/f/lib_Nz4dgQWg-registry/mol_8ZMV7Oqf-rc00000028/edit'
}, {
'gene': 'PRKG1',
'compound': 'RC00000028_3µM_24hr-20221223',
'Type': 'Exon Skip',
'Region': 'chr10:52133840-52133905',
'Sequence (Donor)': 'AGGGGTAAGT',
'PTC Position': 'inFrame',
'Strand': '+',
'Delta psi (Down Intron/ Reference Intron)': -1.0,
'Delta psi (Up Intron/ Alternative Intron)': 1.0,
'CHX Delta psi (Down Intron/ Reference Intron)': None,
'CHX Delta psi (Up Intron/ Alternative Intron)': None,
'diffExon log2FC': -6.786,
'diffExon padj': '1.797e-07',
'CHX diffExon log2FC': None,
'CHX diffExon padj': None,
'diffGene log2FC': -3.214,
'diffGene padj': '1.507e-36',
'CHX diffGene log2FC': None,
'CHX diffGene padj': None,
'htt_activity': 3.0,
'compound_url': 'https://revirtx.benchling.com/revirtx/f/lib_Nz4dgQWg-registry/mol_8ZMV7Oqf-rc00000028/edit'
}, {
'gene': 'SCO1',
'compound': 'RC00000028_3µM_24hr-20221223',
'Type': 'Cassette Exon',
'Region': 'chr17:10695364-10695446',
'Sequence (Donor)': 'GAGGGTACGA',
'PTC Position': '10692957',
'Strand': '-',
'Delta psi (Down Intron/ Reference Intron)': 1.0,
'Delta psi (Up Intron/ Alternative Intron)': 0.994,
'CHX Delta psi (Down Intron/ Reference Intron)': None,
'CHX Delta psi (Up Intron/ Alternative Intron)': None,
'diffExon log2FC': 2.996,
'diffExon padj': '9.549e-06',
'CHX diffExon log2FC': None,
'CHX diffExon padj': None,
'diffGene log2FC': -3.169,
'diffGene padj': 0.0,
'CHX diffGene log2FC': None,
'CHX diffGene padj': None,
'htt_activity': 3.0,
'compound_url': 'https://revirtx.benchling.com/revirtx/f/lib_Nz4dgQWg-registry/mol_8ZMV7Oqf-rc00000028/edit'
}]
},
'filter': {
'type': ['Cassette Exon', 'Alternative splicing site', 'Exon Skip']
}
},
'code': 200,
'message': 'success'
}</code></pre>
<h5>返回参数说明</h5>
<table>
<thead>
<tr>
<th style="text-align: left;">参数名</th>
<th style="text-align: left;">类型</th>
<th>说明</th>
</tr>
</thead>
<tbody>
<tr>
<td style="text-align: left;">table</td>
<td style="text-align: left;">list</td>
<td>表格数据</td>
</tr>
<tr>
<td style="text-align: left;">regions</td>
<td style="text-align: left;">list</td>
<td>表格行数据</td>
</tr>
<tr>
<td style="text-align: left;">compound_url</td>
<td style="text-align: left;">string</td>
<td>药物benchling 链接</td>
</tr>
</tbody>
</table>
<h5>备注</h5>
<p>V14 新增接口， 将原 ”获取 Splicing Target Discovery-Compound 单药物详情页“ 接口表格移到此接口， 并增加筛选项， 表单字段与原接口相同</p>