Splicing Target Discovery-Compound 单药物详情
<p>[TOC]</p>
<h5>简要描述</h5>
<ul>
<li>获取 Splicing Target Discovery-Compound 单药物详情页
<h5>请求URL</h5></li>
<li><code>http://119.136.27.201:3200/discovery/compound/detail</code>
<h5>请求方式</h5></li>
<li>GET</li>
</ul>
<h5>参数</h5>
<table>
<thead>
<tr>
<th style="text-align: left;">参数名</th>
<th style="text-align: left;">必选</th>
<th style="text-align: left;">类型</th>
<th>说明</th>
</tr>
</thead>
<tbody>
<tr>
<td style="text-align: left;">offset</td>
<td style="text-align: left;">是</td>
<td style="text-align: left;">int</td>
<td>分页偏移量</td>
</tr>
<tr>
<td style="text-align: left;">limit</td>
<td style="text-align: left;">是</td>
<td style="text-align: left;">int</td>
<td>分页大小</td>
</tr>
<tr>
<td style="text-align: left;">compound_id</td>
<td style="text-align: left;">是</td>
<td style="text-align: left;">string</td>
<td>药物id，使用discovery/rna_seq 接口中compound_id字段</td>
</tr>
<tr>
<td style="text-align: left;">gene</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">string</td>
<td>gene筛选，多选以“,”分隔</td>
</tr>
<tr>
<td style="text-align: left;">order</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">string</td>
<td>倒序字段，可选："p_value", "q_value", "log2_fold_change", "tpm"</td>
</tr>
<tr>
<td style="text-align: left;">desc</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">int</td>
<td>排序是否倒序 1：是， 0：否 默认1</td>
</tr>
<tr>
<td style="text-align: left;">log2fc_min</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">number</td>
<td>log2fc筛选，填入”log2 FC >“ 框内的数值</td>
</tr>
<tr>
<td style="text-align: left;">log2fc_max</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">number</td>
<td>log2fc筛选，填入”log2 FC <“ 框内的数值</td>
</tr>
<tr>
<td style="text-align: left;">shrink_lfc_min</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">number</td>
<td>shrink_lfc筛选，填入”shrink_lfc >“ 框内的数值</td>
</tr>
<tr>
<td style="text-align: left;">shrink_lfc_max</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">number</td>
<td>shrink_lfc筛选，填入”shrink_lfc <“ 框内的数值</td>
</tr>
<tr>
<td style="text-align: left;">q_value</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">number</td>
<td>q_value筛选，填入”q_value <“ 框内的数值</td>
</tr>
<tr>
<td style="text-align: left;">p_value</td>
<td style="text-align: left;">否</td>
<td style="text-align: left;">number</td>
<td>p_value筛选，填入”p_value <“ 框内的数值</td>
</tr>
</tbody>
</table>
<h5>返回示例</h5>
<pre><code>{
&#039;data&#039;: {
&#039;name&#039;: &#039;RC00000028_3µM_24hr-20230405-RSQP0104/SK-N-SH&#039;,
&#039;default_genes&#039;: &#039;HTT,MSH3,FGFR3,MYB,FOXM1&#039;,
&#039;table&#039;: {
&#039;total&#039;: 1,
&#039;limit&#039;: 1,
&#039;offset&#039;: 0,
&#039;genes&#039;: [{
&#039;gene&#039;: &#039;HPGD&#039;,
&#039;gene_url&#039;: &quot;https://www.genecards.org/cgi-bin/carddisp.pl?gene=FGD2&quot;,
&#039;open_target_url&#039;: &#039;https://platform.opentargets.org/target/ENSG00000105851&#039;,
&#039;ensembl_gene_id&#039;: &#039;ENSG00000164120.14&#039;,
&#039;compound_id&#039;: &#039;RC00000050_3µM_24hr-20230509&#039;,
&#039;log2_fold_change&#039;: -3.487,
&#039;p_value&#039;: &#039;2.228e-32&#039;,
&#039;qvalue&#039;: &#039;5.571e-31&#039;,
&quot;tpm_treat&quot;： 0.1,
&quot;tpm_control&quot;： 0.05,
}]
},
&#039;chart&#039;: [{
&#039;x-axis&#039;: -3.487,
&#039;y-axis&#039;: 30.254,
&#039;tag&#039;: &#039;HPGD&#039;,
&#039;is_highlight&#039;: True
}, {
&#039;x-axis&#039;: -3.471,
&#039;y-axis&#039;: 4.044,
&#039;tag&#039;: &#039;PDCD6-DT&#039;,
&#039;is_highlight&#039;: False
}, {
&#039;x-axis&#039;: -3.47,
&#039;y-axis&#039;: 1.644,
&#039;tag&#039;: &#039;ENSG00000285215&#039;,
&#039;is_highlight&#039;: False
}, {
&#039;x-axis&#039;: -3.462,
&#039;y-axis&#039;: 239.443,
&#039;tag&#039;: &#039;MRPS31&#039;,
&#039;is_highlight&#039;: False
}, {
&#039;x-axis&#039;: -3.433,
&#039;y-axis&#039;: 3.889,
&#039;tag&#039;: &#039;ENSG00000272986&#039;,
&#039;is_highlight&#039;: False
}, {
&#039;x-axis&#039;: -3.432,
&#039;y-axis&#039;: 1.688,
&#039;tag&#039;: &#039;CFAP58-DT&#039;,
&#039;is_highlight&#039;: False
}, {
&#039;x-axis&#039;: -3.366,
&#039;y-axis&#039;: 13.265,
&#039;tag&#039;: &#039;PHC1P1&#039;,
&#039;is_highlight&#039;: False
}, {
&#039;x-axis&#039;: -3.365,
&#039;y-axis&#039;: 1.486,
&#039;tag&#039;: &#039;CAHM&#039;,
&#039;is_highlight&#039;: False
}],
&#039;upregulated_chart&#039;: &#039;http://119.136.27.201:15555/rna_seq_dev/result/RSQP0154/11SpliceR_targets/RC00000050_3µM_24hr-DMSO_24hr/selectivity/DEG-up-RC00000050_3µM_24hr-DMSO_24hr-HTT.pdf&#039;,
&#039;upregulated_table&#039;: {
&#039;(1,2]&#039;: &#039;3238&#039;,
&#039;(2,3]&#039;: &#039;666&#039;,
&#039;(3,4]&#039;: &#039;252&#039;,
},
&#039;downregulated_chart&#039;: &#039;http://119.136.27.201:15555/rna_seq_dev/result/RSQP0154/11SpliceR_targets/RC00000050_3µM_24hr-DMSO_24hr/selectivity/DEG-down-RC00000050_3µM_24hr-DMSO_24hr-HTT.pdf&#039;,
&#039;downregulated_table&#039;: {
&#039;(0,0.1]&#039;: &#039;70&#039;,
&#039;(0.1,0.2]&#039;: &#039;1208&#039;,
&#039;(0.2,0.3]&#039;: &#039;1086&#039;,
},
&#039;deg_chart&#039;: &#039;http://119.136.27.201:15555/rna_seq_dev/result/RSQP0154/11SpliceR_targets/RC00000050_3µM_24hr-DMSO_24hr/selectivity/DEdonor-RC00000050_3µM_24hr-DMSO_24hr.pdf&#039;,
&#039;deg_table&#039;: {
&#039;(0,0.1]&#039;: &#039;3498&#039;,
&#039;(0.1,0.2]&#039;: &#039;781&#039;,
&#039;(0.2,0.3]&#039;: &#039;339&#039;,
}
},
&#039;code&#039;: 200,
&#039;message&#039;: &#039;success&#039;
}</code></pre>
<h5>返回参数说明</h5>
<table>
<thead>
<tr>
<th style="text-align: left;">参数名</th>
<th style="text-align: left;">类型</th>
<th>说明</th>
</tr>
</thead>
<tbody>
<tr>
<td style="text-align: left;">name</td>
<td style="text-align: left;">string</td>
<td>页面标题名称</td>
</tr>
<tr>
<td style="text-align: left;">table</td>
<td style="text-align: left;">list</td>
<td>表格数据</td>
</tr>
<tr>
<td style="text-align: left;">genes</td>
<td style="text-align: left;">list</td>
<td>表格行数据</td>
</tr>
<tr>
<td style="text-align: left;">gene_url</td>
<td style="text-align: left;">string</td>
<td>基因跳转链接</td>
</tr>
<tr>
<td style="text-align: left;">chart</td>
<td style="text-align: left;">list</td>
<td>火山图（散点图）数据</td>
</tr>
<tr>
<td style="text-align: left;">x-axis</td>
<td style="text-align: left;">number</td>
<td>火山图点x轴坐标</td>
</tr>
<tr>
<td style="text-align: left;">y-axis</td>
<td style="text-align: left;">number</td>
<td>火山图点y轴坐标</td>
</tr>
<tr>
<td style="text-align: left;">is_highlight</td>
<td style="text-align: left;">boolean</td>
<td>火上图点是否高亮</td>
</tr>
<tr>
<td style="text-align: left;">tag</td>
<td style="text-align: left;">string</td>
<td>火上图高亮点显示名称</td>
</tr>
<tr>
<td style="text-align: left;">upregulated_chart</td>
<td style="text-align: left;">string</td>
<td>Number of genes upregulated 图片链接</td>
</tr>
<tr>
<td style="text-align: left;">upregulated_table</td>
<td style="text-align: left;">list</td>
<td>Number of genes upregulated 表格内容, 表格字段和内容由后端控制</td>
</tr>
<tr>
<td style="text-align: left;">downregulated_chart</td>
<td style="text-align: left;">string</td>
<td>Number of genes downregulated 图片链接</td>
</tr>
<tr>
<td style="text-align: left;">downregulated_table</td>
<td style="text-align: left;">list</td>
<td>Number of genes downregulated 表格内容</td>
</tr>
<tr>
<td style="text-align: left;">deg_chart</td>
<td style="text-align: left;">string</td>
<td>Number of donors upregulated in DEG 图片链接</td>
</tr>
<tr>
<td style="text-align: left;">deg_table</td>
<td style="text-align: left;">list</td>
<td>Number of donors upregulated in DEG 表格内容</td>
</tr>
<tr>
<td style="text-align: left;">tpm_treat</td>
<td style="text-align: left;">number</td>
<td>TPM (Compound Treated)</td>
</tr>
<tr>
<td style="text-align: left;">tpm_control</td>
<td style="text-align: left;">number</td>
<td>TPM (DMSO)</td>
</tr>
</tbody>
</table>
<h5>备注</h5>
<p>V3.2.2 增加 default_genes 字段， 用于输入用户 wish list 基因, 增加open_target_url用于跳转到open target网站</p>